Depression

Written by

Published Apr 06, 2023

Clinically reviewed by

Reviewed Jun 01, 2021

Overview

  • Depression is a common but serious mental health disorder characterized by persistent feelings of melancholy, hopelessness, or emptiness that make it hard to function in daily life. It affects 1 in 15 adults; over 16% of adults experience it at some point in their lives.
  • It is more than an emotion — it can cause physical pain, intrusive thoughts, and make it difficult to eat, work, sleep, or care for yourself or others.
  • Anyone can be affected regardless of socioeconomic status, race, age, or gender. Depression is almost always multifactorial — it is never someone’s fault.
  • There are many types, including major depressive disorder, persistent depressive disorder, seasonal affective disorder, postpartum depression, and more.
  • Causes include genetics, trauma, life circumstances, medical conditions, substance abuse, hormonal changes, and brain chemistry differences.

Depression is highly treatable. The American Psychiatric Association (APA) reports that 80–90% of people who seek treatment respond positively. Therapy, medication, and lifestyle changes — especially in combination — are effective. Use our depression screening test as a first step toward clarity.

Symptoms of Depression

Symptoms vary by person and may fluctuate day to day or between episodes. They can be emotional, physical, and cognitive. 

  • Altered sleep: Sleeping significantly more or less than usual.
  • Changes in appetite: Overeating, loss of appetite, or loss of interest in food.
  • Concentration & cognition: Inability to concentrate, “fuzzy” thinking, trouble remembering, slowed thoughts or speech.
  • Low energy: Persistent fatigue or sluggishness.
  • Loss of interest: Reduced or absent interest in previously enjoyable activities.
  • Low self-esteem: Diminished self-confidence and feelings of worthlessness.
  • Heightened emotions: Hopelessness, increased agitation, or anger.
  • Intrusive thoughts: Persistent negative thoughts about yourself, triggered or unprompted.
  • Restlessness: Pacing, hand wringing, or inability to stay still.
  • Decision-making difficulties: Trouble making simple or complex decisions.
  • Physical pain: Headaches, back pain, or unexplained pain not resulting from injury.
  • Suicidal thoughts: Thoughts of suicide or suicidal ideation.

Important: Suicidal ideation is a medical emergency. If you are experiencing suicidal thoughts, go to the nearest emergency room or call the National Suicide Prevention Lifeline: 800-273-8255, or call/text 988 for the Suicide and Crisis Lifeline.

How Depression Symptoms Vary by Age

  • Children: Refusing school, being extra clingy to parents, or experiencing physical symptoms such as stomachaches.
  • Older children & adolescents: Difficulties at school, low self-esteem, lack of motivation, and ADHD-like symptoms. Teen depression may also involve eating disorders and substance abuse.
  • Adults: May occur at pivotal life moments. Young adults may experience co-occurring anxiety or eating disorders. Middle-aged adults may experience more physical symptoms and insomnia.
  • Elderly adults: Grief, generalized depressive moods, and feelings of loneliness.

Causes of Depression

Depression is almost always multifactorial — feeling depressed is never someone’s fault. There are several risk factors that may raise the possibility of someone developing depression.

  • Genetics: Having an immediate family member with depression gives you a 40% chance of experiencing it yourself.
  • Trauma: Childhood abuse, sudden loss, war, poverty, or natural disaster can trigger depression. Early or repeated traumas affect how the brain responds to stress.
  • Life circumstances: Major disruptions such as job loss, moving, or divorce can trigger depressive episodes.
  • Medical conditions: Chronic pain, ADHD, sleep disorders, and other conditions increase the likelihood of depression. Some conditions (e.g., hypothyroidism) can mimic depression symptoms. Certain medications can also cause depressive symptoms.
  • Substance abuse: People with substance abuse issues are more likely to experience depression. Alcohol and other substances can worsen symptoms.
  • Hormonal changes: Puberty, pregnancy, postpartum, and menopause can all trigger depression.
  • Brain & biological differences: Differences in pituitary/hypothalamus hormone interaction or neurotransmitter function can contribute to depression.

Risk Factors

  • Being female (a third of women experience a depressive episode in their lifetime)
  • History of trauma: childhood abuse or neglect, death of a loved one, financial hardship, or sudden major life change
  • LGBTQ+ identity, especially without support for identity or lifestyle
  • Family or personal history of mental health conditions (anxiety, eating disorders, PTSD, bipolar disorder, postpartum depression)
  • Chronic illness: fibromyalgia, cancer, heart disease
  • History of substance abuse
  • Taking medications that may cause depressive symptoms (e.g., blood pressure or sleep medications)

According to NAMI, depression raises the risk of cardiovascular and metabolic diseases by 40%. Teens with depression are twice as likely to drop out of high school.

Types of Depression

It’s possible to experience more than one type at once. 

  • Major Depressive Disorder: The “classic” type: persistent symptoms, loss of interest in previously enjoyable activities, difficulty completing daily tasks, and commonly issues with sleep, eating, and weight. May include very low self-esteem and suicidal thoughts. 
  • Persistent Depressive Disorder (Dysthymia): Symptoms persisting for two or more years. May fluctuate in severity while maintaining consistently low mood, sleep/appetite/energy changes, and low self-esteem. 
  • Bipolar Disorder: Bipolar disorder is not depression, but involves cycles between depressive symptoms and mania or euphoria. Requires psychiatric care and medication.
  • Seasonal Affective Disorder (SAD): Depression primarily during darker, colder months, linked to reduced sunlight, social interaction, and exercise. Treated with light therapy, psychotherapy, or medication.
  • Postpartum Depression: Affects 1 in 7 new parents. Distinct from “baby blues,” involves more serious and persistent depressive symptoms beyond two weeks, including extreme sadness, guilt, anxiety about parenting, and difficulty caring for self or baby.
  • Situational Depression: Similar to major depressive disorder but triggered by a specific life event and typically less long-lasting. 
  • Atypical Depression: Like major depressive disorder but with moments of lifted mood in response to positive events, before returning to intense depression. 
  • Premenstrual Dysphoric Disorder (PMDD): Severe PMS-related depression typically affecting women in the week before their period. SSRIs and lifestyle changes can relieve symptoms. 
  • Psychotic Depression: Severe depression with psychotic symptoms such as delusions or hallucinations. Requires treatment for both psychosis and depression.

Treatment

The APA reports 80–90% of people who seek treatment respond positively. Treatment works best when approaches are combined.

1. Therapy

Common approaches: CBT (identifies and changes negative thought patterns), DBT (builds distress tolerance and emotional regulation), Psychodynamic Therapy (explores unconscious patterns and past experiences), and Interpersonal Therapy (addresses relationship problems contributing to depression). Available in-person and virtually. 

2. Medication

The most commonly prescribed antidepressants are SSRIs. Other options include SNRIs, tricyclic antidepressants, and MAOIs. Allow 2–4 weeks to take effect. Never stop abruptly — taper gradually with a doctor’s guidance. 

3. Natural Remedies & Lifestyle Changes

Lifestyle changes accelerate recovery when combined with therapy and medication.

  • Stay active: Exercise releases endorphins and reduces stress. Even a short walk helps.
  • Build healthy routines: Adequate sleep, regular nutritious meals, reduced alcohol intake, and daily practices like meditation or journaling.
  • Talk about it: Trusted people, a therapist, or a support group provide a safe space. Keeping feelings bottled up worsens depression.
  • Be realistic: Healing involves possible setbacks. Be compassionate with yourself. Deciding to seek help is an enormous first step.

Types of Depression

Just as symptoms of depression may be experienced differently by different people, depression itself has many variations. Types of depression vary according to the kind of symptoms people experience, the circumstances that trigger the depression, as well as other overlapping mental health conditions that have depressive symptoms.

It’s possible to experience more than one type of depression at once. The best way to find out what type of depression you are experiencing is to visit your doctor or psychiatrist for a diagnosis. For example, you might be someone who has bipolar disorder and experiences postpartum depression after having a baby. Or you may have a persistent depressive disorder which gets exacerbated by seasonal affective disorder in the wintertime.

When someone with unipolar depression, known as major depression, has accompanying psychosis, it’s called depression with psychosis or psychotic depression.

Depressive Psychosis

A person who experiences atypical depression may experience many of the same symptoms as someone who has major depressive disorder, but they are also able to experience moments of happiness and a lifting of the depression symptoms. This may happen when they receive good news or are otherwise cheered up in some way. However, when these feelings die down, this person is still likely to slip into an intense and all encompassing depression.

Atypical Depression

When you experience situational depression, you may experience many of the same symptoms as major depressive disorder, but your depression may be triggered by a specific situation or major life event, and may not be as long lasting as major depressive disorder. Triggers may include the death of a loved one, a divorce or breakup, or any sudden or major life change.

Situational Depression

Sources

  1. What is Depression?
    American Psychiatric Association. Accessed October 2020.
  2. Relationship of Neurotransmitters to the Symptoms of Major Depressive Disorder.
    David J. Nutt. J Clin Psychiatry. 2008;69 Suppl E1:4-7.
  3. 2018 NSDUH Detailed Tables. Substance Abuse and Mental Health Services Administration.
    Substance Abuse and Mental Health Services Administration: SAMHSA. Published August 2019.
  4. Mental Health by the Numbers.
    National Alliance on Mental Illness. Updated March 2021.
  5. Depression.
    National Alliance on Mental Illness. Updated August 2017.
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What are the common signs of depression?

The most recognizable signs are persistent feelings of sadness, hopelessness, or emptiness; loss of interest in activities that were previously enjoyable; significant changes in sleep and appetite; low energy or fatigue; difficulty concentrating; feelings of worthlessness or guilt; and in severe cases, suicidal thoughts. Physical symptoms like unexplained pain, headaches, or digestive issues are also common. Symptoms must persist for at least two weeks and significantly impair daily functioning to meet the threshold for a clinical diagnosis.

How do you get diagnosed with depression?

Depression is typically diagnosed when symptoms have persisted for at least two weeks and significantly impacted daily life. Because certain medical conditions — thyroid issues, hormonal imbalances, vitamin deficiencies — can mimic depression, a full medical workup is recommended before a formal diagnosis. Once other causes are ruled out, a doctor or mental health professional uses a clinical interview and standardized assessment to make the diagnosis. A depression screening test can be a useful first step.

Who can diagnose depression?

Psychiatrists, psychologists, licensed therapists, and primary care physicians are all qualified to diagnose depression. For a formal diagnosis and access to medication, a psychiatrist or physician is typically required. A primary care doctor is often the first point of contact and can conduct initial screening, order relevant lab work to rule out medical causes, and refer to a specialist if needed.

Can an online therapist diagnose depression?

A licensed therapist practicing via telehealth can evaluate and diagnose depression. Online therapy is also an effective and accessible treatment option — CBT, DBT, and other approaches used for depression are available virtually. Online psychiatry can support medication management as well.

What type of therapy is best for depression?

CBT is the most widely researched and commonly recommended therapy for depression — it directly targets the negative thought patterns that drive and sustain the condition. DBT is particularly effective for people who also experience emotional dysregulation or self-harm. Psychodynamic therapy is valuable when depression is rooted in unresolved past experiences. Interpersonal therapy is helpful when relationship problems are a significant contributing factor. Most people benefit from a combination tailored to their specific circumstances.

When should you seek professional help for depression?

Seek help if feelings of sadness, hopelessness, or loss of interest have persisted for two weeks or more and are meaningfully interfering with your ability to work, maintain relationships, or care for yourself. Do not wait until symptoms become severe. If you or someone you know is experiencing suicidal thoughts, seek help immediately by calling or texting 988 (Suicide and Crisis Lifeline) or going to the nearest emergency room.

Can depression be treated?

Yes — highly effectively. The APA reports that 80–90% of people who seek treatment respond positively. Treatment is most effective when multiple approaches are combined: therapy, medication, and lifestyle changes work more powerfully together than any single approach alone. Even severe depression is treatable. If someone you know is struggling, encourage them to seek treatment.

How prevalent is depression?

Depression affects as many as 1 in 15 adults, and over 16% of adults will experience it at some point in their lives. A third of women experience a depressive episode during their lives. Having an immediate family member with depression gives you a 40% chance of experiencing it yourself. According to NAMI, depression also raises the risk of cardiovascular and metabolic diseases by 40%.

Are there any risk factors for depression?

Key risk factors include: being female; a history of trauma (childhood abuse, loss, financial hardship); identifying as LGBTQ+ without support; family or personal history of mental health conditions; chronic illness; substance abuse; and taking medications that can cause depressive symptoms. These factors increase vulnerability — they do not make depression inevitable.

Do depression symptoms look different with age?

Yes. Children may refuse school or develop stomachaches. Teens may struggle academically and experience eating disorders or substance abuse. Young adults often have co-occurring anxiety or eating disorders. Middle-aged adults may experience more physical symptoms and insomnia. Elderly adults may experience grief, generalized depression, and loneliness.

What types of medications are prescribed for depression?

The most common are SSRIs. Other options include SNRIs, tricyclic antidepressants, and MAOIs. The right choice depends on the type of depression, side effects, and individual response. Allow 2–4 weeks to take effect; never stop abruptly — taper gradually with your doctor.

What self-help strategies work for depression?

Effective self-help strategies include regular physical activity (even light movement releases endorphins), building healthy routines (consistent sleep, nutritious eating, reduced alcohol, journaling or meditation), talking to trusted people or joining a support group, and setting realistic expectations about recovery. These work best alongside — not instead of — professional treatment.

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