Trazodone: for depression and anxiety

Psychiatry appointments online, from anywhere. Our licensed psychiatric clinicians diagnose and treat depression and anxiety. Get medications like Trazodone for your treatment plan.

What is Trazodone?

Trazodone is a type of antidepressant medication. It’s most commonly used as an antidepressant but it’s also used as a sleep-aid in some cases. It treats depression and anxiety by increasing the availability of serotonin in the brain.

What is Trazodone used for?

Trazodone can be prescribed to treat a number of mental health conditions, including depression and anxiety. Some conditions Trazodone treats include:

How Talkspace psychiatry works

Complete a brief assessment

Answer a few questions and we’ll match you with an online prescriber who meets your needs

Schedule your initial session

Once matched, schedule your live video psychiatry session.

Begin your treatment

Your online psychiatry prescriber will personalize your treatment, which may include medication and follow-ups.

Connect with a licensed prescriber

Get specialized psychiatric treatment from a licensed prescriber — all from the comfort of your home.


With Talkspace Psychiatry, the first step toward getting help is to complete a brief assessment. Once you’re matched with a psychiatric clinician, you’ll have a live video session where you’ll share how you’ve been feeling. From there, they’ll prescribe a treatment plan — if that includes a prescription (such as Trazodone), you can get it from your local pharmacy.

Trazodone (brand names Desyrel, Desyrel Dividose, Oleptro, and Trazodone D) is taken in different forms, dosages, and frequencies, depending on your mental health condition and the treatment plan prescribed by your provider. Trazodone is prescribed in low doses, taken several times every day.

It’s important to take Trazodone and its generic form, Desyrel, Desyrel Dividose, Oleptro, and Trazodone D, exactly as prescribed by your clinician. Side effects of Trazodone are often mild, but can include nausea, dry mouth, dizziness, headache, constipation, trouble sleeping, changes in appetite or sex drive, and more. Seek immediate medical attention if you experience thoughts of suicide, worsening depression, or aggressive behavior.

Trazodone is an effective sleep aid that can help individuals fall asleep and stay asleep. When taken in low doses, trazodone won’t cause you to develop a tolerance or experience sleepiness throughout the day.  Since trazodone is not classified as a controlled substance by the FDA, it isn’t considered to come with the risk of misuse and abuse. It can be highly effective at treating insomnia, and since it’s more affordable than other sleep aids, it is often the first choice for many struggling individuals. 

Trazodone and Xanax are two different drugs belonging to different drug classifications. Trazodone is considered an antidepressant and Xanax is a benzodiazepine most often used to treat anxiety. While sometimes a doctor will prescribe trazodone off-label to treat anxiety, it is not predominantly an anxiety medication. There is an overlap in side effects between these two drugs, but they are distinct.  Unlike trazodone, Xanax can be addictive.

Trazodone is an antidepressant that works to restore serotonin in the brain. It has been seen to improve mood, appetite, and energy levels while decreasing anxiety and insomnia as side effects of depression. 

Trazodone works swiftly and its drowsiness effects can often be felt in only thirty minutes making it an option for a sleep-aid. However, you should only use Trazodone as a sleep-aid if prescribed specifically for that use by your doctor.

There are several different medications your psychiatrist may prescribe for depression or anxiety. 

Other medications for anxiety include:

  • Bupropion
  • Paxil 
  • Buspirone

Other medications for depression include:

  • Fluoxetine 
  • Escitalopram
Talk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment. It’s up to your psychiatric clinician’s professional judgment whether medication is prescribed. If you are in a life threatening situation – don’t use this site. Call +1 (800) 273-8255 or use these resources to get immediate help.