10 Latuda Alternatives to Consider

Published on: 17 Jan 2025
Clinically Reviewed by Reshawna Chapple, PhD, LCSW
10 Alternatives to Latuda

Latuda (lurasidone) is an atypical antipsychotic drug prescribed to treat bipolar depression and schizophrenia. It’s effective in managing symptoms like mood swings, hallucinations, and delusions. Yet, despite how well medications like Latuda work, some people are looking for an alternative due to Latuda’s side effects, cost, or simply a preference for a more natural approach to care. 

Alternatives for Latuda range from other drug options to non-pharmaceutical treatments. The best choice depends on your individual needs and preferences. If you’re looking for a Latuda alternative, talk to a healthcare provider to determine the most suitable treatment plan for your condition. 

Continue reading to learn more about alternatives for Latuda that you might want to consider.

Alternative Medications to Latuda

If you’re looking for pharmaceutical alternatives to Latuda, you have several options to choose from. Below are some of the most commonly prescribed medications used to treat bipolar disorder and schizophrenia.

Medication NameGeneric NameMedication ClassConditions TreatedTop Side Effects
AbilifyAripiprazoleAtypical AntipsychoticSchizophrenia Bipolar IDepression (adjunct)InsomniaWeight gain Dizziness
SeroquelQuetiapineAtypical AntipsychoticBipolar disorder SchizophreniaDrowsinessDry mouth Weight gain
LithiumLithiumMood StabilizerBipolar disorderIncreased thirst TremorsNausea
RisperdalRisperidoneAtypical AntipsychoticSchizophrenia Bipolar IWeight gainFatigueTremors
ZyprexaOlanzapineAtypical AntipsychoticSchizophrenia Bipolar IBipolar Depression (w/fluoxetine)Weight gain Sedation Dry mouth

Abilify (aripiprazole)

Abilify (aripiprazole) is a versatile atypical antipsychotic that works by balancing dopamine and serotonin levels in the brain. Similar to Latuda, it’s commonly prescribed to treat schizophrenia and bipolar disorder. For individuals with schizophrenia, Abilify can help manage challenging symptoms such as hallucinations and delusions, fostering a clearer sense of reality. In bipolar disorder, it’s highly effective at stabilizing mood swings, and preventing the extreme highs of mania and the deep lows of depression.

Common side effects of Abilify include:

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While these effects may vary, your healthcare provider can guide you in managing them effectively.

Seroquel (quetiapine)

Seroquel (quetiapine) is another widely used atypical antipsychotic that helps balance serotonin and dopamine levels in the brain. It’s an effective Latuda substitute, particularly for treating schizophrenia, as it targets key pathways associated with symptoms like hallucinations, disorganized thinking, and delusions.

For bipolar disorder, Seroquel offers comprehensive support by treating both manic and depressive episodes, as well as helping to maintain long-term stability. This dual action makes it a valuable option for managing the full spectrum of bipolar symptoms.

Seroquel comes in two formulations to suit different needs: an immediate-release version for quicker action and an extended-release version for sustained effects throughout the day.

Common side effects of Seroquel include:

  • Drowsiness
  • Dry mouth
  • Weight gain
  • Increased cholesterol
  • High blood sugar
  • Dizziness

These effects may vary, and your healthcare provider can recommend strategies to minimize them.

Lithium

Lithium, a well-known mood stabilizer, has been one of the oldest, most well-established treatments on the market for bipolar disorder. This time-tested medication works by regulating neurotransmitters like serotonin, helping to balance mood and prevent the extreme lows that characterize bipolar disorder. In addition to stabilizing depressive episodes, long-term use of Lithium is also effective at preventing manic episodes, making it a crucial part of long-term bipolar management.

While Lithium is not typically used as a first-line treatment for schizophrenia, it may be prescribed as an adjunct therapy for individuals who experience symptoms overlapping both bipolar disorder and schizophrenia. This makes it a versatile option in complex cases of comorbidity.

Lithium requires careful management and regular monitoring through blood tests, as its levels need to be closely tracked for safety and effectiveness. Only a healthcare professional can safely prescribe and manage Lithium treatment.

Common side effects of Lithium include:

  • Increased thirst
  • Diarrhea
  • Nausea
  • Tremors
  • Frequent urination

Regular check-ups are essential to help mitigate these effects and ensure safe use.

Risperdal (risperidone)

Risperdal (risperidone) is a second-generation antipsychotic that works by regulating dopamine and serotonin levels in the brain. It’s widely prescribed for treating both schizophrenia and bipolar depression, offering effective relief from the challenging symptoms of each.

For schizophrenia, Risperdal is highly effective in reducing symptoms such as hallucinations and delusions, helping individuals regain a sense of reality. It’s known for its ability to decrease the intensity of psychotic episodes, promoting better overall functioning in daily life.

In bipolar disorder, Risperdal is typically used to manage manic or mixed episodes, where it can help reduce impulsivity, agitation, and other symptoms commonly associated with mania. However, it’s not typically used as a standalone treatment for bipolar depression. Instead, it’s often part of a combined approach alongside mood stabilizers or antidepressants for comprehensive symptom management.

Common side effects of Risperdal include: 

  • Weight gain
  • Fatigue
  • Tremors
  • Increased appetite

These side effects may vary, and monitoring is essential to ensure optimal treatment.

Zyprexa (olanzapine)

Zyprexa (olanzapine) is an atypical antipsychotic that helps stabilize mood and regulate thought patterns by balancing dopamine and serotonin levels in the brain. 

For individuals with schizophrenia, Zyprexa can provide significant relief by reducing hallucinations and delusions, and promoting clearer thinking and emotional stability. In the treatment of bipolar disorder, Zyprexa is effective for managing manic and mixed episodes. When combined with fluoxetine, it can also help alleviate symptoms of bipolar depression, reducing irritability and impulsive behavior often seen during manic phases.

Common side effects of Zyprexa include: 

  • Weight gain
  • Sedation
  • Increased blood sugar and cholesterol
  • Dry mouth
  • Constipation 

Regular monitoring may be necessary to manage these effects effectively.

Natural/Non-Pharmaceutical Alternatives to Latuda

If you’re looking for a non-pharmaceutical approach to care, there are several natural alternatives to Latuda you might consider as part of your treatment plan. The following work best when used under medical supervision or professional guidance.

Cognitive behavioral therapy (CBT)

Cognitive behavioral therapy (CBT) is a structured, evidence-based form of talk therapy that helps people recognize and change negative, unhealthy thought and behavior patterns. By focusing on the connection between thoughts, emotions, and behaviors, CBT can be a powerful tool in managing both bipolar disorder and schizophrenia.

In the treatment of schizophrenia, CBT is often used as an adjunct therapy alongside medication. It helps individuals understand and manage symptoms like delusions and hallucinations, fostering better insight into their experiences. Additionally, CBT is valuable in enhancing emotional resilience and improving social functioning, areas that can be particularly challenging for those with schizophrenia.

For bipolar disorder, CBT is effective in identifying triggers and early warning signs of mood episodes, allowing individuals to take proactive steps to manage their condition. It also focuses on developing coping skills to manage depressive thoughts and reduce anxiety, helping individuals gain more control over their emotions and reactions.

Mindfulness and meditation

Mindfulness practices, including meditation and deep breathing exercises, are powerful tools for reducing stress and promoting emotional regulation. By encouraging individuals to stay present in the moment and fostering nonjudgmental acceptance of thoughts and emotions, mindfulness can significantly enhance overall mental well-being and provide valuable support in treating conditions like bipolar disorder and schizophrenia.

“Insight-oriented therapy, supportive therapy, and cognitive behavioral therapy are all great options for patients with bipolar disorder. In certain situations, after the individual therapy has addressed the core issues, having a couples therapy session is helpful to improve the relationship and provide insight into the condition for the patient’s partner and family.”

Talkspace psychiatrist Dr. Muhammad Munir

In schizophrenia, mindfulness-based techniques can be particularly beneficial for managing symptoms like hallucinations and delusions. By cultivating awareness of the present moment, mindfulness helps individuals detach from intrusive thoughts, reducing their emotional impact and making it easier to navigate challenging experiences.

For bipolar disorder, mindfulness supports individuals in recognizing early signs of mood changes, allowing them to respond proactively. Regular mindfulness practice can help reduce the intensity and frequency of mood swings, contributing to greater emotional stability and improved coping strategies during both manic and depressive episodes.

Exercise

Regular physical activity is widely recognized for its positive impact on mood and overall mental health. By increasing endorphin levels and reducing stress hormones, exercise plays a key role in enhancing well-being. Research consistently shows a strong link between physical activity and improved mental health. When combined with medication, exercise can be an effective strategy for managing symptoms of schizophrenia and bipolar disorder by regulating mood, reducing stress, and promoting brain health.

Specific to schizophrenia, exercise can help with social withdrawal and lack of motivation. For bipolar disorder, it can play a critical role in mood stabilization and alleviating depressive symptoms. 

In the case of schizophrenia, exercise can help combat social withdrawal and lack of motivation, common challenges faced by individuals with the condition. For bipolar disorder, regular physical activity is crucial in mood stabilization, helping to alleviate depressive symptoms and potentially reduce the frequency and intensity of mood swings. 

Dietary changes

Nutrition plays a vital role in supporting mental health and well-being. A diet rich in Omega-3 fatty acids, antioxidants, and essential vitamins supports brain health and emotional stability. While diet alone can’t replace medication and therapy, research suggests Omega-3 fatty acids, in particular, may offer significant benefits in the treatment of bipolar disorder and schizophrenia.

Support groups

Peer-led groups provide emotional support, practical advice, and a sense of community for people living with bipolar disorder or schizophrenia. They can offer comfort and support by ensuring people feel less alone and know that someone else understands what they’re going through. 

Considerations When Choosing a Latuda Alternative

If you’re looking for alternatives to Latuda, consider several factors, including the following: 

  • Personal health history: Certain medications may not be suitable for people with preexisting conditions, such as heart disease or kidney issues.
  • Side effect profiles: Some alternatives come with the risk of new or different side effects, which should be weighed against their potential benefits.
  • Cost: Financial accessibility is essential when creating a care plan, especially when considering the need for long-term treatments.
  • Lifestyle compatibility: Some treatments require dietary changes, regular monitoring, or strict adherence to dosing schedules. It’s important to understand these and consider whether they’ll fit into your lifestyle. 

You must consult a doctor or therapist before switching or stopping any medication. Otherwise, you risk the possibility of Latuda withdrawal.

”A thorough psychiatric evaluation is always helpful before any medication recommendations are considered. A partial or poor response to medication is a key factor to consider. At times, combinations of medications are required to address all the symptoms. In certain patients with a poor response, genetic testing can be helpful in understanding metabolic pathways and how they affect the response to medications, helping to minimize side effects and improve clinical outcomes.”

Talkspace psychiatrist Dr. Muhammad Munir

Find the Right Alternative with Talkspace 

Finding the right alternative to Latuda to treat bipolar disorder or schizophrenia is a complex process. Even if it seems overwhelming, you’re not alone. Talkspace offers online access to licensed psychiatric providers and therapists who can help you develop a treatment plan that works for you. Whether you need medication management, alternative prescriptions, or therapy tailored to your needs, Talkspace is here to support you. 

Connect with an online psychiatrist to learn about a Latuda prescription and its alternatives today.

Sources:

  1. Citrome L, Weiden PJ, McEvoy JP, et al. Effectiveness of lurasidone in schizophrenia or schizoaffective patients switched from other antipsychotics: a 6-month, open-label, extension study. CNS Spectrums. 2013;19(4):330-339. doi:10.1017/s109285291300093x. https://pmc.ncbi.nlm.nih.gov/articles/PMC4140225/. Accessed November 24, 2024.
  2. Mahindru A, Patil P, Agrawal V. Role of Physical Activity on Mental Health and Well-Being: A review. Cureus. Published online January 7, 2023. doi:10.7759/cureus.33475. https://pmc.ncbi.nlm.nih.gov/articles/PMC9902068/. Accessed November 27, 2024.
  3. Shakeri J, Khanegi M, Golshani S, et al. Effects of omega-3 supplement in the treatment of patients with bipolar I disorder. International Journal of Preventive Medicine. 2016;7(1):77. doi:10.4103/2008-7802.182734. https://pmc.ncbi.nlm.nih.gov/articles/PMC4882968/. Accessed November 24, 2024.
  4. Amminger GP, Schäfer MR, Schlögelhofer M, Klier CM, McGorry PD. Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study. Nature Communications. 2015;6(1). doi:10.1038/ncomms8934. https://www.nature.com/articles/ncomms8934#Sec2. Accessed November 24, 2024.

Talkspace articles are written by experienced mental health-wellness contributors; they are grounded in scientific research and evidence-based practices. Articles are extensively reviewed by our team of clinical experts (therapists and psychiatrists of various specialties) to ensure content is accurate and on par with current industry standards.

Our goal at Talkspace is to provide the most up-to-date, valuable, and objective information on mental health-related topics in order to help readers make informed decisions.

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