Medications to Treat Attention-deficit/Hyperactivity Disorder (ADHD)

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Published Nov 23, 2021

Overview

  • ADHD medication includes stimulant and non-stimulant options, and working with a psychiatrist helps determine the safest and most effective treatment plan.
  • Stimulants are the most commonly prescribed ADHD medications and are effective for most people, while non-stimulants offer alternatives with lower misuse risk.
  • Combining ADHD medication with therapy and behavioral strategies often leads to better symptom management outcomes.

If you have an attention deficit hyperactivity disorder (ADHD) diagnosis and are finding it difficult to manage, you might be wondering when it’s time to see a psychiatrist. When you start considering medication to help manage ADHD, it’s important that you understand your options. Working with your doctor or an online psychiatrist can help you determine which treatment approach is the best fit for you.

It’s important to keep in mind that the most effective ADHD treatment often involves more than medication alone. You may benefit from a multimodal approach that combines medication with behavioral strategies, therapy, education, and skills training.

While ADHD can’t be cured, according to research in The New England Journal of Medicine, appropriate treatment can significantly improve focus, impulse control, and daily functioning. Keep reading to learn more about the types of ADHD medication available, how to get an ADHD prescription, and what to expect from treatment.

Types of Medications Used to Treat ADHD

There are several ADHD medications you might consider. We're taking a closer look at the more common ones in the following ADHD medication list:

Prescription Stimulants (long-acting/extended-release)

Long-acting/extended-release stimulants have been used to treat ADHD for decades. They're the most commonly prescribed ADHD medication to treat ADHD in children, and they're actually the most well-researched ADHD drug for both children and adults. Stimulant drugs can help you focus your thoughts while ignoring external distractions. According to research published in Frontiers in Neuroscience, stimulant medications are effective for approximately 70-80% of people diagnosed with ADHD.

They slowly and gradually increase norepinephrine and dopamine levels and activity in your brain. Since they're "long-acting," they take effect and wear off slowly through the day, which can help reduce major side effects.

Stimulants are effective for a wide range of ages, including children, adolescents, teens, and adults. Within the class of stimulants, there are two types of ADHD medications: methylphenidate and amphetamine salts. Extended-release stimulants are most often taken once a day in the morning.

Types of methylphenidate long-acting stimulants to treat ADHD:

  • Ritalin-SR
  • Focalin XR
  • Concerta
  • Daytrana
  • Methylin-ER
  • Metadate CD
  • Ritalin-LA
  • QuilliChew-ER
  • Quillivant XR
  • Aptensio-XR

Types of amphetamine long-acting stimulants to treat ADHD:

  • Adderall-XR
  • Adzenys XR ODT
  • Azstarys
  • Vyvanse
  • Evekeo
  • Adderall-XR
  • Dyanavel-XR

Possible side effects of long-acting stimulants to treat ADHD:

  • Loss of appetite
  • Weight loss
  • Irritability
  • Social withdrawal
  • Anxiety
  • Sleeping issues
  • Rebound effect
  • Tics or uncontrollable muscle movement
  • Minor growth delay

The Food and Drug Administration (FDA) has concerns that both amphetamine and methylphenidate stimulants might make psychiatric and heart problems more likely.

Prescription Stimulants (short-acting/immediate release)

Short-acting stimulants are typically taken every four hours when needed. Like long-acting stimulants, short-acting/immediate-release stimulants also target a neurotransmitter called dopamine. This brain chemical helps control emotional responses and movement while also playing a major role in motivation.

Types of methylphenidate short-acting stimulants to treat ADHD:

  • Ritalin
  • Focalin
  • Methylin Oral Solution
  • Methylin

Types of amphetamine short-acting stimulants to treat ADHD:

  • Dexedrine
  • Adderall
  • ProCentra Oral Solution
  • Evekeo
  • Zenzedi

Possible side effects of short-acting stimulants to treat ADHD:

  • Loss of appetite
  • Weight loss
  • Sleeping issues
  • Irritability
  • Tics

Non-Stimulant Medication

As an alternative to stimulant ADHD medications used for ADHD treatment, non-stimulant ADHD medications are also an option. These typically take longer to begin working after the dose adjustment, and the full effect of the ADHD meds may not be felt or seen for several weeks.

On the positive side, however, non-stimulants typically don't cause as many sleep issues or agitation. Nor do some of them result in a lack of appetite, which can be important in younger children. Non-stimulants are also used in conjunction with stimulants as part of the treatment plan by your psychiatrist. Finally, non-stimulants don't have the same risk of addiction or abuse as some other ADHD medications used for ADHD do.

Non-stimulant ADHD medication boosts levels of norepinephrine in the brain. Increasing norepinephrine helps with emotional stability and executive functioning. People who take certain non-stimulants to treat their ADHD may be able to begin and finish tasks more quickly and efficiently with an increased attention span. They may also find a significant decrease in impulsivity, distractibility, and hyperactivity.

Types of non-stimulants to treat ADHD:

  • Atomoxetine
  • Clonidine ER
  • Guanfacine ER
  • Intuniv
  • Kapvay
  • Strattera
  • Tenex
  • Viloxazine
  • Qelbree

Possible side effects of non-stimulants to treat ADHD:

  • Fatigue
  • Nausea
  • Upset stomach
  • Mood swings
  • Loss of appetite (in certain ADHD medications)
  • Dry mouth
  • Vomiting
  • Dizziness

Antidepressants

Sometimes antidepressants can be used off-label to treat ADHD. Using a drug off-label means it's used by doctors even though it hasn't officially been approved by the FDA for use with a specific medical or mental health condition.

In 2004, the FDA added a black box label about an apparent link between a higher risk of suicide in adults who use depression ADHD medication for ADHD. This risk seems to be increased in the first 1 – 2 months of use. However, research published in Frontiers in Psychiatry, among others, has questioned the overall impact of this warning, noting that declines in antidepressant prescriptions were associated with increases in suicidal events among people with severe depression.

Certain antidepressant drugs, known as selective serotonin reuptake inhibitors (SSRIs), bupropion, or venlafaxine, are potentially effective in treating ADHD. Sometimes these are used in combination with other ADHD medications for comorbid depression and anxiety with ADHD symptoms.

Antidepressants are similar to stimulants in that they help raise levels of certain chemicals in the brain, like norepinephrine and dopamine. These two chemicals, when increased, can help improve attention span in those who have ADHD. They are also helpful in reducing impulsivity, hyperactivity, and aggression.

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Types of antidepressants to treat ADHD:

  • Wellbutrin

Possible side effects of antidepressants to treat ADHD:

  • Dry mouth
  • Weight loss
  • Low blood pressure
  • Tremors
  • Drowsiness
  • Blurred vision
  • Upset stomach

*Note: Side effects can differ based on the type of antidepressant drug you're taking for your ADHD. Some meds may cause a rapid heart rate, while others can cause anxiety and headaches. It's important to let your doctor know about any side effects you're feeling if you begin taking an antidepressant or ADHD medication.

Here's a quick overview of side effects:

Medication class Common side effects Less common side effects Serious concerns
Long-acting stimulants Loss of appetite, weight loss, sleeping issues, irritability Social withdrawal, anxiety, rebound effect, tics Minor growth delay, potential psychiatric or heart problems (FDA concern)
Short-acting stimulants Loss of appetite, weight loss, sleeping issues, irritability Tics, uncontrollable muscle movements Potential for misuse if not monitored
Non-stimulants Fatigue, nausea, upset stomach, mood swings, dry mouth Vomiting, dizziness, loss of appetite (certain medications) Generally lower risk profile than stimulants
Antidepressants Dry mouth, drowsiness, upset stomach Weight loss or gain, low blood pressure, tremors, blurred vision Black box warning for increased suicide risk (first 1-2 months)

If you experience any concerning side effects, contact your prescriber immediately. Side effects often decrease as your body adjusts to the ADHD medication.

Medications Commonly Prescribed for ADHD

You have many options for ADHD medication to treat ADHD. Finding the right ADHD medication can take some time. Understand that often, a multimodal treatment (a combination of treatments) is the most effective option for many people who have ADHD.

Be patient, talk to your doctor, and know that taking enough time to figure out the right ADHD medication, dosage, and schedule can really pay off in the end. Talk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above ADHD medications before starting any treatment.

Name brand Generic Type Description
Strattera Atomoxetine Non stimulant A cognitive-enhancing ADHD medication that treats symptoms of ADHD.
Intuniv ER Guanfacine Non stimulant Thought to affect receptors in parts of the brain that can strengthen working memory and reduce distraction. Also seems to improve impulse control and attention.
Tenex Guanfacine hydrochloride tablets Non stimulant Off-label use for ADHD treatment. Can be used alone or with a stimulant.
Ritalin Methylphenidate hcl Short-acting methylphenidate Changes the amounts of certain natural substances in the brain to treat ADHD.
Methylin Methylphenidate hcl Short-acting methylphenidate Central nervous system stimulant used primarily to treat ADHD.
Ritalin-SR Methylphenidate hcl Longer-acting methylphenidate Treats ADHD and narcolepsy.
QuilliChew-ER Methylphenidate hydrochloride Longer-acting methylphenidate Central nervous system stimulant prescription for ADHD medication.
Aptensio-XR Methylphenidate hydrochloride Longer-acting methylphenidate Treats symptoms of ADHD and narcolepsy. Can be used alone or with other ADHD medications.
Adderall Dextroamphetamine mixed salts Short-acting amphetamine A central nervous system stimulant used to treat the symptoms of hyperactivity and impulse control. Can be used alone or with other ADHD medications.
Zenzedi Dextroamphetamine sulfate Short-acting amphetamine Prescription medicine that can be used alone or with other ADHD medications to treat symptoms of ADHD.
Adderall-XR Dextroamphetamine mixed salts Longer-acting amphetamine A stimulant that's used to treat ADHD and narcolepsy.
Dyanavel-XR Amphetamine extended-release Longer-acting amphetamine A central nervous system (CNS) stimulant that treats ADHD. Can help increase attention and decrease impulsiveness and hyperactivity.
Wellbutrin Bupropion hcl Antidepressant Not a first-line ADHD medication for ADHD, but can help treat symptoms in some people.
Tofranil Imipramine Antidepressant Useful in treating additional symptoms of depression or anxiety that are common in those who have ADHD.

ADHD Medication Dosage Ranges

ADHD medication dosing varies based on factors like age, symptoms, and how you respond to treatment. Providers typically start with a low dose and adjust gradually to balance effectiveness and side effects. Always follow your prescriber’s guidance and avoid making changes on your own.

Medication Type Age Group Typical Starting Approach Adjustment Timeline
Stimulants (methylphenidate, amphetamines) Children Low dose based on weight or age Adjust every 1–2 weeks
Stimulants (methylphenidate, amphetamines) Adults Low to moderate starting dose Adjust based on response
Non-stimulants (atomoxetine, guanfacine, clonidine) Children Gradual dose increase over time May take several weeks
Non-stimulants (atomoxetine, guanfacine, clonidine) Adults Start low and titrate slowly Adjust over several weeks

This table provides a general overview, but exact dosage ranges vary widely depending on the specific medication and individual needs. Your healthcare provider will guide all dosing decisions to ensure safety and effectiveness.

How to Get ADHD Medication

If you're thinking about starting any child or adult ADHD medication, it's important to talk to your doctor or psychiatrist first. Learning as much as you can about a potential ADHD medication and its side effects can enhance the likelihood that your treatment will be both effective and productive.

Your doctor may prescribe one or more types of ADHD medication. To start treatment, you should follow the steps below:

  1. Get diagnosed: If you’re unsure whether your symptoms align with ADHD, reviewing common ADHD symptoms in adults can help you better understand what to look for before seeking an evaluation. ADHD assessments might include a physical examination, a series of interviews, and other feedback.
  2. Begin therapy or treatment: The most effective form of treatment for most people with ADHD is a multimodal treatment plan; consider combining therapy with your ADHD medication.
  3. Discuss your options for medication: Learn about the different types of ADHD medication available.
  4. Talk to a psychiatrist: A psychiatrist can prescribe the right ADHD medication.

Should You Treat ADHD with Medication?

Being cautious of ADHD medication is a valid concern. With all ADHD medications, there's a potential risk for substance use challenge, especially if you don't have a formal diagnosis. Whether or not you treat your ADHD with ADHD medication is a personal decision.

There's no right or wrong answer, and only through research and talking with your psychiatrist and prescriber can you make the best decision on primary care for you or your loved one. Understanding the pros and cons of medications can help you make your decision. Take all the side effects of ADHD meds into consideration and be sure to ask your prescriber about anything you want clarification on or are unsure about.

Questions to ask your prescriber:

  • Should I consider medication to treat ADHD?
    Only you can decide if the pros outweigh the cons when it comes to taking medication for ADHD. After reviewing all the side effects, it should be easier to determine if any of the medications used for ADHD are worth trying.
  • What are the possible side effects of this medication?
    It’s important to fully understand the side effects of ADHD medication. This can help you make the best decision in terms of which type of medication you might find the most beneficial.
  • Are there any other treatments I should be considering?
    Keep in mind that medication alone isn’t always the most effective way to treat ADHD. Most often, a multimodal treatment approach — where a combination of medication, therapy, and other forms of treatment is applied — is going to produce the best results in managing ADHD.
  • Should I consider treatment in conjunction with this medication?
    The same treatment techniques will not be right for everyone’s ADHD. It’s important to consider all the options you have when coming up with your treatment plan.
  • Are there any holistic or self-help techniques I can try?
    There are multiple self-help techniques and non-medication options that might help improve your ADHD symptoms.
  • Should I consider therapy in addition to medication?
    When used together, therapy and medication have been found to be very effective in treating symptoms of ADHD.
  • Are there any other conditions going on that could be contributing to my ADHD?
    Because ADHD commonly occurs with other mental health conditions and disorders, it offers extra challenges during the diagnosis and treatment phase. It’s common to have additional learning disorders, depression, or anxiety along with ADHD. The National Resource Center on ADHD
  • Open states that more than 66% of people who have ADHD also have at least one other mental health condition.

Brand Name Vs. Generic ADHD Medications

Brand-name and generic ADHD medications contain the same active ingredients and meet the same FDA quality standards, but they differ in cost, availability, and sometimes individual response.

Here's a side-by-side breakdown to help you compare your options:

Brand name Generic equivalent Key difference
Adderall Dextroamphetamine mixed salts Generic widely available; lower cost
Ritalin Methylphenidate HCl Generic widely available; lower cost
Concerta Methylphenidate ER Some generics use different delivery mechanisms
Strattera Atomoxetine Generic available since 2017
Vyvanse Lisdexamfetamine No generic currently available

Inactive ingredients like fillers and binders can vary between brand and generic versions, which may affect how some individuals respond. Insurance plans often require trying a generic before approving a brand-name prescription. Your psychiatrist can review your response to either option and adjust your prescription accordingly.

ADHD Medication Insurance Coverage & Cost Considerations

The cost of ADHD medications varies widely depending on your insurance coverage, whether you choose brand or generic versions, and your specific prescription plan.

Insurance coverage considerations

Most insurance plans cover ADHD medications, but they often have preferred drug lists. Your plan may require trying generic versions before approving brand-name prescriptions.

Prior authorization is common for ADHD medications, especially controlled substances. Your psychiatrist may need to submit additional documentation explaining why a specific ADHD medication is medically necessary for you.

Copays differ significantly between generic and brand-name options. Generic ADHD medications typically have lower copays, often $10 to $30 per month, and brand-name versions can cost $50 to $200 or more monthly.

Cost-saving strategies

Check if your insurance offers mail-order pharmacy options for 90-day supplies. This often reduces per-month costs compared to monthly refills at retail pharmacies.

Ask your psychiatrist about patient assistance programs offered by pharmaceutical manufacturers. Many companies provide discounts or free ADHD medication for people who qualify based on income.

Compare prices at different pharmacies. Costs can vary by $20 to $50 or more for the same prescription. Some discount programs and apps help you find the lowest prices.

Consider whether a generic version works as well for you. The savings can be substantial without sacrificing effectiveness for many people.

Non-Pharmacological Treatments for ADHD

While ADHD medication can be effective, combining it with other approaches to support ADHD treatment often leads to better outcomes. These evidence-based strategies can support symptom management and improve daily functioning.

  • Behavioral therapy: Helps you build practical coping strategies, such as improving organization, time management, and impulse control.
  • Cognitive behavioral therapy (CBT): Focuses on identifying and changing unhelpful thought patterns, improving emotional regulation, and strengthening problem-solving skills.
  • Skills training: Targets specific challenges in daily life, such as managing finances, improving communication, or increasing productivity at work or school.
  • Regular physical activity: Exercise may help improve focus, reduce hyperactivity, and support overall mood and mental well-being.
  • Sleep hygiene: Maintaining consistent sleep routines and reducing screen time before bed can help manage attention and energy levels.
  • Stress management techniques: Practices like mindfulness, meditation, or yoga can support emotional regulation and reduce feelings of overwhelm.
  • Balanced nutrition: Eating regular, nutrient-rich meals may help stabilize energy levels and support focus throughout the day.
  • Omega-3 fatty acids: Found in fish or supplements, omega-3s may offer modest benefits for some people, though research is still ongoing.

Talk to your healthcare provider about which combination of treatments may work best for you. A multimodal approach can help address ADHD from multiple angles for more sustainable results.

Start Your ADHD Treatment Journey with Talkspace

Managing ADHD is rarely a one-size-fits-all process. The right combination of medication, therapy, and lifestyle strategies depends on your symptoms, health history, and personal goals.

Working closely with a qualified psychiatric provider gives you the best chance of finding a plan that genuinely works. Talkspace connects you with licensed psychiatric providers who can evaluate your needs, discuss medication options, and provide ongoing support. If you are ready to take the next step, explore online ADHD treatment through Talkspace and get the care you deserve from the comfort of home.

Frequently Asked Questions (FAQs)

How long does ADHD medication take to work?

Stimulant ADHD medications usually start working within 30 to 60 minutes, with effects lasting several hours depending on the formulation. Non-stimulant options may take a few weeks to build up in your system and reach full effectiveness.

Can you take ADHD medication while pregnant or breastfeeding?

Most ADHD medications are not typically recommended during pregnancy or breastfeeding due to limited safety data, though decisions depend on individual circumstances. Your doctor can help weigh the risks and benefits and discuss alternative strategies if needed.

What should I do if my ADHD medication stops working?

If your ADHD medication becomes less effective, your psychiatrist may adjust your dose, switch medications, or recommend additional treatments. It’s important not to make changes on your own and to seek medical guidance for safe adjustments.

Are ADHD medications addictive?

Some stimulant ADHD medications have the potential for misuse, but when taken as prescribed, the risk of addiction is low. Non-stimulant medications do not carry the same risk and may be an option for some individuals.

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Sources

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  7. Food and Drug Administration. Suicidality in Children and Adolescents Being Treated With Antidepressant Medications. FDA. Published online November 3, 2018. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/suicidality-children-and-adolescents-being-treated-antidepressant-medications. Accessed April 21, 2026.
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