Hydroxyzine Pamoate (Vistaril): online prescription management for anxiety & insomnia

Psychiatry appointments online, from anywhere. Our licensed psychiatric clinicians diagnose and treat conditions like anxiety and insomnia. See if medications like Hydroxyzine Pamoate are right for you.

What is Hydroxyzine Pamoate?

Hydroxyzine Pamoate (or Vistaril) is an antihistamine medication related to others like Benadryl or Zyrtec. Hydroxyzine Pamoate can be prescribed as a short-term treatment option for anxiety and insomnia.

What is Hydroxyzine Pamoate used for?

Hydroxyzine Pamoate (and its name brand version, Vistaril) can be prescribed to treat a number of mental health conditions, including anxiety. It works by affecting the histamine and serotonin levels in the body, reducing anxiety and helping you sleep. Some conditions Hydroxyzine Pamoate treats include:

How Talkspace psychiatry works

Complete a brief assessment

Answer a few questions and we’ll match you with an online prescriber who meets your needs

Schedule your initial session

Once matched, schedule your live video psychiatry session.

Begin your treatment

Your online psychiatry prescriber will personalize your treatment, which may include medication and follow-ups.

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You’ll start with completing a brief assessment online. We’ll then match you with a psychiatric clinician where you’ll discuss your symptoms over a video call. Based on their evaluation, you will be prescribed a treatment plan. If that includes a prescription (such as Hydroxyzine Pamoate), you can pick it up from your local pharmacy. 

Depending on your mental health condition and the treatment plan provided by your psychiatrist, Hydroxyzine Pamoate (Vistaril) may be prescribed to you in one of many different forms. The dosage and frequency will depend on your prescription. However, Hydroxyzine Pamoate is usually taken on a short-term basis before other medications start working.

It’s important to take Hydroxyzine Pamoate and its brand name, Vistaril, exactly as your clinician has advised with your prescription. Side effects of Hydroxyzine Pamoate are often mild, but can include drowsiness, nausea, dry mouth, dry eyes and blurred vision. Seek immediate medical attention if you experience seizures, uncontrolled movement, rash, swelling, fever, or sores.

Hydroxyzine is used to treat and control tension and anxiety. It can be an effective way to manage anxiety and, when used with other medications, can promote sleep before surgical procedures. It’s also commonly prescribed for people living with sleep disorders like insomnia. 

Hydroxyzine has a sedative property, making it an potential option to be used in promoting sleep. It can be prescribed for people with diagnosed sleep disorders, but it’s only recommended if 7-8 hours of sleep is feasible. 

It’s recommended that you take Hydroxyzine at bedtime. However, you should always consult with a doctor first. Effects will be felt within 15-30 minutes of taking this drug.

There are several drugs that should not be taken with Hydroxyzine as they might increase the risk of QT prolongation (abnormal heart rhythm). It’s recommended that you don’t take the following with hydroxyzine: arsenic trioxide, chlorpromazine, droperidol, mefloquine, moxifloxacin, pentamidine, pimozide, probucol, quinidine, sotalol, tacrolimus, or thioridazine.

There are several different medications your psychiatrist may prescribe for anxiety or insomnia.

Other medications for anxiety include:

    • Buspar (Buspirone)
    • Lexapro (Escitalopram)
    • Propranolol (Hemangeol)
    • Zoloft (Sertraline)
    • Depakote (divalproex sodium) 



Talk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment. It’s up to your psychiatric clinician’s professional judgment whether medication is prescribed. If you are in a life threatening situation – don’t use this site. Call +1 (800) 273-8255 or use these resources to get immediate help.